Jan J Enghild Selected Research

Hereditary Corneal Dystrophies

1/2021	Mutation-induced dimerization of transforming growth factor-β-induced protein may drive protein aggregation in granular corneal dystrophy.
11/2020	Protein Analysis of the TGFBIR124H Mouse Model Gives Insight into Phenotype Development of Granular Corneal Dystrophy.
1/2020	Biochemical mechanisms of aggregation in TGFBI-linked corneal dystrophies.
1/2019	The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation.
1/2018	Proteomic profiling of TGFBI-null mouse corneas reveals only minor changes in matrix composition supportive of TGFBI knockdown as therapy against TGFBI-linked corneal dystrophies.
12/2017	Mutation-Induced Deamidation of Corneal Dystrophy-Related Transforming Growth Factor β-Induced Protein.
11/2017	Structural and Functional Implications of Human Transforming Growth Factor β-Induced Protein, TGFBIp, in Corneal Dystrophies.
4/2016	Near-complete 1H, 13C, 15N resonance assignments of dimethylsulfoxide-denatured TGFBIp FAS1-4 A546T.
3/2016	Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
2/2016	LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).

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Jan J Enghild Research Topics

Disease

22	Hereditary Corneal Dystrophies 01/2021 - 12/2004
12	Inflammation (Inflammations) 01/2020 - 10/2002
10	Amyloid Plaque 01/2019 - 03/2012
8	Neoplasms (Cancer) 01/2021 - 08/2003
5	Alzheimer Disease (Alzheimer's Disease) 01/2019 - 11/2004
5	Lung Injury 10/2014 - 05/2002
4	Vision Disorders (Hemeralopia) 12/2017 - 02/2011
3	Periodontitis 12/2021 - 01/2010
3	Arthritis (Polyarthritis) 01/2021 - 01/2009
3	Parkinson Disease (Parkinson's Disease) 01/2020 - 03/2014
3	Rheumatoid Arthritis 01/2020 - 11/2014
3	Amyloidosis 01/2019 - 01/2013
2	Blindness (Hysterical Blindness) 01/2021 - 10/2012
2	Proteostasis Deficiencies 01/2019 - 12/2004
2	Infections 01/2017 - 01/2009
2	Disease Progression 02/2016 - 07/2014
2	Chronic Periodontitis 03/2015 - 11/2014
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2013 - 05/2012
2	Anhedonia 12/2012 - 01/2007
2	Pneumonia (Pneumonitis) 01/2011 - 10/2003
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 03/2010 - 10/2003
2	Fibrosis (Cirrhosis) 03/2010 - 10/2003
2	Corneal Diseases (Corneal Disease) 06/2007 - 09/2005
2	Ischemia 10/2002 - 10/2002
2	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 10/2002 - 10/2002
1	Diabetic Neuropathies (Diabetic Neuropathy) 10/2020
1	Retinal Detachment (Retinal Detachments) 10/2020
1	Neoplasm Metastasis (Metastasis) 06/2020
1	Bites and Stings (Sting) 01/2020
1	Hemolysis 01/2020
1	Neuralgia (Stump Neuralgia) 01/2019
1	Herpes Simplex Encephalitis (Herpes Encephalitis) 01/2019
1	Hyperalgesia 01/2019
1	Pain (Aches) 01/2019
1	Peripheral Nerve Injuries 01/2019
1	Dementia (Dementias) 01/2017
1	Cataract (Cataracts) 01/2017
1	Corneal Opacity 03/2016
1	Juvenile Epithelial of Meesmann Corneal Dystrophy 03/2016

Drug/Important Bio-Agent (IBA)

39	Proteins (Proteins, Gene)FDA Link 01/2021 - 10/2002
13	Amyloid (Amyloid Fibrils)IBA 01/2020 - 12/2010
8	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2021 - 10/2012
8	betaIG-H3 protein (keratoepithelin)IBA 02/2016 - 08/2003
6	Peptide Hydrolases (Proteases)FDA Link 12/2021 - 10/2002
6	Transforming Growth Factor beta (TGF-beta)IBA 07/2015 - 03/2012
6	Receptor for Advanced Glycation End ProductsIBA 01/2011 - 09/2003
5	ProteomeIBA 10/2020 - 09/2005
5	Peptides (Polypeptides)IBA 01/2019 - 12/2010
3	Complement System Proteins (Complement)IBA 01/2020 - 01/2017
3	SynucleinsIBA 01/2020 - 03/2014
3	AntibodiesIBA 01/2019 - 06/2005
3	Serine Proteases (Serine Protease)IBA 01/2019 - 09/2012
3	Virulence Factors (Pathogenicity Factors)IBA 01/2017 - 01/2010
3	EnzymesIBA 01/2017 - 05/2002
3	Biomarkers (Surrogate Marker)IBA 08/2013 - 06/2004
3	Bleomycin (Blenoxane)FDA LinkGeneric 03/2010 - 09/2003
3	AntioxidantsIBA 10/2002 - 05/2002
2	Extracellular Matrix ProteinsIBA 01/2021 - 12/2004
2	Matrix Metalloproteinases (MMPs)IBA 06/2020 - 02/2004
2	High-Temperature Requirement A Serine Peptidase 1IBA 01/2020 - 01/2013
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2019 - 02/2016
2	Hyaluronic Acid (Hyaluronan)IBA 10/2019 - 01/2009
2	GlycosaminoglycansIBA 08/2017 - 01/2016
2	Lysine (L-Lysine)FDA Link 04/2016 - 10/2008
2	LipopolysaccharidesIBA 01/2016 - 10/2014
2	SerpinsIBA 01/2015 - 08/2003
2	Trans Fatty AcidsIBA 01/2013 - 05/2012
2	Hydroxyproline (4 Hydroxyproline)IBA 03/2010 - 10/2003
2	Immunoglobulin G (IgG)IBA 04/2007 - 06/2005
2	AEOL 10150IBA 10/2002 - 10/2002
1	Protease Inhibitors (Protease Inhibitor)IBA 01/2021
1	Nerve Growth Factors (Neurotrophins)IBA 10/2020
1	SolutionsIBA 01/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2020
1	Proteoglycans (Proteoglycan)IBA 01/2020
1	Apolipoproteins E (ApoE)IBA 01/2020
1	Protein Isoforms (Isoforms)IBA 01/2020
1	ApolipoproteinsIBA 01/2020
1	Chondroitin Sulfates (Chondroitin Sulfate)IBA 10/2019
1	NeurotensinIBA 01/2019
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2019
1	InterferonsIBA 01/2019
1	sortilinIBA 01/2019
1	Neurotensin Receptors (Neurotensin Receptor)IBA 01/2019
1	Intrinsically Disordered ProteinsIBA 01/2018
1	Heparin (Liquaemin)FDA LinkGeneric 08/2017
1	rhamnolipidIBA 01/2017
1	Pancreatic Elastase (Elastase)IBA 01/2017
1	ClathrinIBA 01/2017
1	Tyrosine (L-Tyrosine)FDA Link 01/2017
1	pigment epithelium-derived factorIBA 01/2017
1	CyanatesIBA 04/2016
1	CathelicidinsIBA 04/2016
1	Dimethyl Sulfoxide (DMSO)FDA LinkGeneric 04/2016
1	Keratin-12 (Keratin 12)IBA 03/2016
1	Keratins (Keratin)IBA 03/2016

Therapy/Procedure

7	Therapeutics 01/2020 - 08/2003
3	Lasers (Laser) 04/2014 - 03/2012
1	Cataract Extraction 01/2017
1	Slit Lamp 03/2016